GLP-1 Receptor Agonist

Semaglutide Calculator

For educational purposes only. Not medical advice. Full disclaimer
EV
Elena Vasquez, Biochemistry Updated January 2025 · Reviewed by Ryan Peters

Calculate how to mix and dose Semaglutide (Ozempic/Wegovy) — just pick your vial and week.

New to Semaglutide? Start Here

What is it? Semaglutide is a weight loss and blood sugar medication (brand names: Ozempic, Wegovy). It's injected once per week — same day each week.

What does "reconstitution" mean? If you have a powder vial, you add bacteriostatic water (BAC water) to turn it into liquid. BAC water is sterile water with a tiny preservative that keeps it safe for weeks.

What is "titration"? It means starting at a low dose and slowly increasing over time. This prevents nausea and other side effects. You increase every 4 weeks.

How do I read the syringe? You'll use an insulin syringe with 100 "units" marked on it. The calculator tells you exactly how many units to draw.

Semaglutide Titration Guide

Important: Semaglutide is dosed once weekly and requires gradual titration to reduce side effects.

Weeks 1-4

0.25mg

Weeks 5-8

0.5mg

Weeks 9-12

1mg

Weeks 13-16

1.7mg

Weeks 17+

2.4mg

Standard Semaglutide Titration Schedule

0.25mg Weeks 1-4 0.5mg Weeks 5-8 1.0mg Weeks 9-12 1.7mg Weeks 13-16 2.4mg Weeks 17+ Dose Progression Over Time

Increase dose every 4 weeks. Stay at current dose longer if side effects persist.

Check your vial label

Bacteriostatic water — how many ml to add

Where you are in the protocol

4

Your Weekly Injection

Weekly Dose

0.25

mg per week

Draw Per Dose

10

units on syringe

Concentration

2500

mcg/ml

Standard Titration Schedule

Weeks Weekly Dose Purpose
1–4 0.25 mg Initial titration
5–8 0.5 mg Dose escalation
9–12 1 mg Therapeutic dose
13–16 1.7 mg Escalation (if needed)
17+ 2.4 mg Maximum/maintenance

* This follows the standard titration protocol. Some may remain at lower doses based on tolerability and response.

How to Use This Calculator

  1. Select your vial size – Choose the amount of semaglutide in your vial (3mg, 5mg, or 10mg).
  2. Enter BAC water amount – Input how much bacteriostatic water you'll add. The default of 2ml works well for most vial sizes.
  3. Select your current week – Choose which phase of the titration schedule you're in. The calculator automatically adjusts the dose based on the standard protocol.
  4. Read your results – The calculator shows your weekly dose, how many units to draw, and the concentration. Semaglutide is injected once weekly.

About Semaglutide

Semaglutide works by mimicking a natural hormone (GLP-1) that your body releases after eating. This hormone tells your brain "I'm full" — semaglutide amplifies that signal so you feel satisfied with less food.

Key effects include:

  • Reduces appetite — you feel less hungry throughout the day
  • Slows stomach emptying — food stays in your stomach longer, keeping you full
  • Improves blood sugar control
  • May support heart health

Important Note

Semaglutide is a prescription medication. This calculator is for educational purposes only. Always use under medical supervision and follow your healthcare provider's dosing instructions.

Frequently Asked Questions

Gradual dose increases help minimize gastrointestinal side effects (nausea, vomiting, diarrhea) which are common when starting GLP-1 agonists. Starting low and increasing slowly allows your body to adjust.
Stay at your current dose longer before increasing, or step back to the previous dose. Many people find that side effects improve over time. Contact your healthcare provider if side effects are severe or persistent.
No. Many people achieve their goals at lower doses (1mg or 1.7mg). The goal is to find the lowest effective dose that works for you. Higher doses aren't necessarily better and may increase side effects.

Done Calculating? Track Your Daily Doses

Set up your protocol once, then come back daily to log injections, monitor vial usage, and stay on schedule.

Open Daily Dose Tracker
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