PT-141 Calculator
Calculate PT-141 (Bremelanotide) reconstitution and dosing. Works for both men and women.
New to PT-141? Start Here
What is it? PT-141 (Bremelanotide) works through the nervous system rather than blood flow. It's FDA-approved (as Vyleesi) for certain conditions in women.
How it works: It activates melanocortin receptors in the brain, which play a role in arousal and desire. Unlike other medications, it works centrally - in your brain.
Key point: Effects take 30-60 minutes to begin and can last 12-24+ hours. Do not use more than once per 24 hours.
PT-141 Quick Reference
Starting Dose
0.5-1 mg
assess tolerance first
Standard Dose
1-2 mg
most common range
Onset
30-60 min
lasts 12-24+ hours
Calculate Your Dose
Enter your vial info and desired dose
Check your vial label
ml of water added
Per use, max 1x per 24 hours
Your Results
Draw Per Dose
20
units on syringe
Concentration
5000
mcg per ml
Doses Per Vial
10
at this dose
What 20 units looks like:
How to Use PT-141
Start Low
First time? Start with 0.5-1mg to assess tolerance. Nausea is the most common side effect, and it's dose-dependent.
Timing Matters
Inject 30-60 minutes before desired effects. Peak effects occur around 2-4 hours and can last 12-24+ hours.
Injection Site
Subcutaneous injection - stomach, thigh, or arm. Same technique as other peptides.
Frequency Limits
Do NOT use more than once in 24 hours. Limit to 2-3 times per week maximum. Overuse can cause desensitization.
Common Side Effects
- Nausea - Most common, usually mild. Worse at higher doses. Tends to decrease with repeated use.
- Facial flushing - Temporary warmth/redness in face
- Mild headache - Usually resolves quickly
- Fatigue - Some feel tired after effects wear off
Taking with food may reduce nausea but can slow onset. Most people prefer taking on empty stomach.
Dosing Guidelines
Women
FDA-approved dose: 1.75 mg (Vyleesi)
Research range: 0.5-2 mg
Starting dose: 0.5-1 mg
Women often respond well to lower doses. Start low and increase if needed.
Men
Typical range: 1-2 mg
Starting dose: 1 mg
Maximum: 2 mg (rarely needed)
Most men find 1-1.5 mg effective. Higher doses increase side effects without proportional benefit.
Frequently Asked Questions
PT-141 typically begins working within 30-60 minutes after injection. Peak effects occur around 2-4 hours. Unlike other medications that work in minutes, PT-141 works through the central nervous system which takes longer. The effects can persist for 12-24+ hours in many people.
Maximum once per 24 hours, and most protocols recommend limiting use to 2-3 times per week. Overuse can lead to:
- Receptor desensitization (reduced effectiveness)
- Increased side effects
- Potential skin hyperpigmentation with long-term frequent use
PT-141 works through a completely different mechanism - it acts on melanocortin receptors in the brain (specifically MC4R). This means:
- It affects desire/arousal, not just physical response
- Works for both men and women
- Effects are more psychological/emotional
- Can work even when other methods don't
PT-141 can generally be used alongside other peptides like BPC-157, TB-500, or GH peptides. However:
- Don't mix in the same syringe (use separate injections)
- Some find Melanotan II has similar but longer-lasting effects (PT-141 is a metabolite of MT2)
- Always start one peptide at a time to assess individual effects
Not everyone responds to PT-141. If it's not working:
- Try a slightly higher dose (up to 2mg)
- Make sure you're giving it enough time (full effects at 2-4 hours)
- Some people are non-responders due to melanocortin receptor genetics
- Psychological factors still play a role - it's not a magic switch
If you don't respond after 2-3 tries at appropriate doses, you may be a non-responder.