BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a naturally occurring protein in human gastric juice. It has gained significant attention in the research community for its remarkable tissue-healing properties, including tendon, ligament, muscle, and gut repair. Getting the dosage right is critical for achieving desired outcomes while maintaining safety.
What Is BPC-157?
BPC-157 is a 15-amino acid peptide fragment that demonstrates potent healing effects across multiple tissue types. It works primarily through upregulating growth factor expression, promoting angiogenesis (new blood vessel formation), and modulating nitric oxide pathways. Unlike many peptides, BPC-157 is stable in gastric acid, making it effective both orally and via injection.
BPC-157 Dosage Chart
| Use Case | Daily Dose | Route | Duration |
|---|---|---|---|
| General healing support | 250-500mcg | Subcutaneous | 4-6 weeks |
| Tendon/ligament injury | 500-750mcg | Subcutaneous near site | 6-8 weeks |
| Gut healing | 250-500mcg | Oral or subcutaneous | 4-8 weeks |
| Muscle injury recovery | 500mcg | Subcutaneous near site | 4-6 weeks |
| Post-surgical recovery | 500-750mcg | Subcutaneous | 4-8 weeks |
How to Calculate Your BPC-157 Dose
Step 1: Reconstitute the Peptide
BPC-157 typically comes in 5mg vials as a lyophilized powder. Add bacteriostatic water to reconstitute:
| Water Added | Concentration | 250mcg Dose | 500mcg Dose |
|---|---|---|---|
| 1mL | 5mg/mL (5000mcg/mL) | 0.05mL (5 units) | 0.10mL (10 units) |
| 2mL | 2.5mg/mL (2500mcg/mL) | 0.10mL (10 units) | 0.20mL (20 units) |
| 3mL | 1.67mg/mL (1667mcg/mL) | 0.15mL (15 units) | 0.30mL (30 units) |
Step 2: Choose Your Injection Volume
Using a standard insulin syringe (100 units = 1mL), draw the appropriate amount based on your reconstitution concentration. Injecting closer to the injury site is generally preferred for localized injuries.
Step 3: Determine Frequency
Most protocols call for once or twice daily injections. Splitting the daily dose into two administrations (morning and evening) may provide more consistent peptide levels throughout the day.
Dosing by Body Weight
| Body Weight | Conservative Dose | Standard Dose | Higher Dose |
|---|---|---|---|
| Under 150 lbs (68kg) | 200mcg/day | 350mcg/day | 500mcg/day |
| 150-200 lbs (68-91kg) | 250mcg/day | 500mcg/day | 750mcg/day |
| Over 200 lbs (91kg+) | 350mcg/day | 500mcg/day | 750mcg/day |
BPC-157 Cycle Protocol
A typical BPC-157 cycle follows this pattern:
- Week 1-2: Start at a conservative dose to assess tolerance
- Week 3-6: Move to standard dose if well-tolerated
- Week 7-8: Continue if healing is still progressing, or begin tapering
- Post-cycle: No PCT required; take 2-4 weeks off before another cycle
Oral vs Injectable BPC-157
| Factor | Oral | Injectable (Subcutaneous) |
|---|---|---|
| Best for | Gut-related issues | Musculoskeletal injuries |
| Bioavailability | Lower systemic availability | Higher systemic availability |
| Dose needed | May need higher doses | Standard doses effective |
| Convenience | Easy (capsule or liquid) | Requires injection preparation |
| Onset | Slower for systemic effects | Faster systemic distribution |
Frequently Asked Questions
How much BPC-157 should I take per day?
The most common daily dose of BPC-157 is 250-500mcg for general healing and up to 750mcg for more significant injuries. Most people start at 250mcg to assess tolerance before increasing. The dose can be taken once daily or split into two administrations.
How long should a BPC-157 cycle last?
A typical BPC-157 cycle lasts 4-8 weeks depending on the injury or condition being addressed. Some people run shorter 4-week cycles for minor issues, while more significant injuries may benefit from 6-8 weeks. A 2-4 week break between cycles is generally recommended.
Do I need to cycle off BPC-157?
While BPC-157 does not require post-cycle therapy (PCT) and has no known hormonal effects, taking periodic breaks (2-4 weeks between cycles) is considered best practice. This allows the body to respond to the healing stimulated during the cycle and helps prevent receptor desensitization.
Conclusion
BPC-157 dosing depends on your specific goals, body weight, and the severity of the condition being addressed. Starting conservatively at 250mcg daily and adjusting based on response is the most prudent approach. Always use proper reconstitution techniques and sterile injection practices for safety.